Ba/F3 Models

Customized Services for Kinase Drug Target Validation

Ba/F3 Models

Ba/F3 cells are IL-3 dependent murine pro-B cells that, upon genetic engineering, can be rendered dependent on the activity of specific kinases (e.g., EGFR, ALK, RET, TRK), making them a powerful tool for kinase target validation, inhibitor screening, and resistance mechanism studies.

Leveraging our expertise in cell engineering, PRECEDO has established a Ba/F3 stable cell line library covering more than 40 kinase targets, along with corresponding Ba/F3-derived CDX animal models to support kinase drug evaluation from molecular to cellular to in vivo levels. Services include:

  • Generation of kinase-dependent cell lines
  • Kinase inhibitor activity screening
  • Construction and validation of resistant mutants
  • In vivo efficacy studies using Ba/F3 CDX models

All models are rigorously validated with comprehensive data reports and are available for custom development based on client needs.

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Precision Models for Your Research

Not finding what you need? Submit a custom sample request to access models tailored to your specific research requirements.

Reprogramming Cells, Empowering Medicine

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