PDO Models
Patient-Derived Organoids — Clinically Relevant Models for Confident Drug Decisions
PDO Models
PRECEDO has established three core organoid technology platforms: normal organoid-based toxicity evaluation, tumor organoid-based efficacy assessment, and organoid-immune co‑culture systems, providing clinically relevant models to support drug development, precision medicine, and translational research.
1. Organoid-Based Toxicity Evaluation
Approximately 30% of drug candidates fail during clinical trials due to toxicity not detected in preclinical studies, with hepatotoxicity and cardiotoxicity being the leading causes. Organoid technology offers a more physiologically relevant platform for toxicity evaluation, bridging the gap between traditional models and human responses.
PRECEDO has developed a comprehensive library of normal tissue-derived organoids (oral mucosa, lung, skin) and iPSC-derived organoids (liver, intestine, kidney, lung, brain, cardiac) to test drug-induced toxicity in vitro, supporting early safety screening and toxicology studies.
Key Advantages:
- Human-Relevant Background : Derived from healthy donor tissues, providing more accurate prediction of human drug toxicity
- Multi-Organ Coverage: Supports evaluation of hepatotoxicity, nephrotoxicity, gastrointestinal toxicity, pulmonary toxicity, and more
- High-Throughput Screening: Compatible with 96/384 well formats for rapid, multi‑concentration screening
- Functional Relevance: Maintains organ-specific functions (e.g., CYP enzyme activity in liver, transporter activity in kidney)
2. Tumor Organoid-Based Efficacy Assessment
PRECEDO has established a patient-derived organoid (PDO) biobank covering more than 20 cancer types, with ongoing expansion, delivering predictive data for drug development and clinical decision making.
Key Advantages:
- Multi-Dimensional Data: Maintains the original tumor’s mutation profile and phenotypic characteristics, integrating clinical, pathological, and drug response data
- Clinically Relevant: Drug responses correlate closely with patient outcomes
- Broad Cancer Coverage: Lung, colorectal, breast, gastric, pancreatic, ovarian, hematologic malignancies, and more
- Standardized Readouts: Provides IC50, combination indices, and other pharmacodynamic parameters
3. Organoid-Immune Co-Culture Models
PRECEDO has developed a tumor organoid-immune co-culture platform that reconstructs the tumor‑immune microenvironment in vitro, enabling evaluation of immunotherapies—including immune checkpoint inhibitors, bispecific antibodies, and adoptive cell therapies.
Key Advantages:
- Recapitulates the Tumor Microenvironment : Models tumor-immune cell interactions
- Broad Immune Cell Compatibility: Supports PBMCs, T cells, NK cells, and CAR‑T cells
- Multi-Parameter Readouts: Assesses tumor cell killing, immune cell activation, and cytokine secretion
- Autologous Pairing: Patient-matched tumor organoids and immune cells available
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