DMPK

From early screening to IND-enabling studies, we deliver reliable data that meets global regulatory standards.

Large Molecule Capabilities

  • Modality type: peptides, peptide-drug conjugates (PDC), Antibody-drug conjugates (ADC), antibodies (Ab), proteins
  • Payload release of ADCs in liver lysosomes/S9/homogenate, cathepsin, tumor cells
  • In vitro metabolic stability in blood, plasma, serum
  • Payload-containing metabolite identification
  • Drug antibody ratio (DAR) distribution
  • Intact mass, reduced mass and peptide mapping analysis
  • In vivo PK studies in rodents, dogs, monkeys
  • In vivo exploratory toxicity (MTD, DRF/TK) studies in rodents, dogs, monkeys
  • Sample bioanalysis by ligand binding assays (LBA) with plate readers, MSD, and LC-MS/MS methodologies

DMPK

Reprogramming Cells, Empowering Medicine

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Sample Request

Registration of Human Sample Requirements

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Sample Request

Registration of Human Sample Requirements

Action
Remove
Submit